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pentobarbital decreases levels of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers can lower panobinostat ranges by ~70% and bring on therapy failure.pentobarbital will minimize the extent or impact of rabeprazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Import